Targeting cancer stem cells in carcinoma: an overview of recent trends and potential therapeutic options

Title: Targeting cancer stem cells in carcinoma: an overview of recent trends and potential therapeutic options.

Authors: Khwaja F, Tabassum S.

Journal: Expert Opinion on Therapeutic Targets. 2021 Jul;25(7):705-717.

Summary: This research review article provides an overview of recent trends in the targeting of cancer stem cells (CSCs) in carcinoma and potential therapeutic options. CSCs are a small population of cells within tumors that have the ability to self-renew and differentiate into various cell types, and they are thought to play a key role in tumor initiation, progression,

and resistance to therapy. The article discusses various strategies for targeting CSCs, including the use of small molecule inhibitors, antibodies, and natural compounds. The authors also discuss the potential of combination therapies that target both CSCs and non-CSC tumor cells to improve treatment outcomes. Additionally, the article highlights the importance of understanding the complex mechanisms underlying CSC biology and the development of biomarkers to identify CSCs in order to improve the efficacy of CSC-targeted therapies. The authors conclude that targeting CSCs in carcinoma is a promising therapeutic approach that has the potential to improve patient outcomes and reduce the risk of tumor recurrence. However, further research is needed to better understand the biology of CSCs and develop more effective CSC-targeted therapies.

Overall, this research study highlights the ongoing efforts to develop new and effective treatments for carcinoma by targeting cancer stem cells. While further research is needed, this approach shows promise for improving patient outcomes and reducing the risk of tumor recurrence.

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