Targeting cancer stem cells in carcinoma: an overview of recent trends and potential therapeutic options
Title : Targeting cancer stem cells in carcinoma: an overview of recent trends and potential therapeutic options. Authors: Khwaja F, Tabassum S. Journal: Expert Opinion on Therapeutic Targets. 2021 Jul;25(7):705-717. Summary: This research review article provides an overview of recent trends in the targeting of cancer stem cells (CSCs) in carcinoma and potential therapeutic options. CSCs are a small population of cells within tumors that have the ability to self-renew and differentiate into various cell types, and they are thought to play a key role in tumor initiation, progression, and resistance to therapy. The article discusses various strategies for targeting CSCs, including the use of small molecule inhibitors, antibodies, and natural compounds. The authors also discuss the potential of combination therapies that target both CSCs and non-CSC tumor cells to improve treatment outcomes. Additionally, the article highlights the importance of understanding the complex mechanisms unde...